75000 - Document - Document and Entity Information
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75010 - Statement - Consolidated Balance Sheets
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75020 - Statement - Consolidated Balance Sheets (Parenthetical)
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75030 - Statement - Consolidated Statements of Operations and Comprehensive Loss
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75040 - Statement - Consolidated Statements of Stockholders' Equity
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75050 - Statement - Consolidated Statements of Cash Flows
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995455 - Disclosure - Cybersecurity Risk Management, Strategy, and Governance
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995465 - Disclosure - Nature of the Business and Basis of Presentation
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995475 - Disclosure - Summary of Significant Accounting Policies
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995485 - Disclosure - Fair Value Measurements
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995495 - Disclosure - Cash Equivalents and Marketable Securities
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995505 - Disclosure - Property and Equipment, Net
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995515 - Disclosure - Additional Balance Sheet Detail
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995525 - Disclosure - Preferred Stock
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995535 - Disclosure - Common Stock
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995545 - Disclosure - Stock-based Compensation Expense
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995555 - Disclosure - License and Collaboration Agreements
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995565 - Disclosure - License Agreements
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995575 - Disclosure - Leases
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995585 - Disclosure - Commitments and Contingencies
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995595 - Disclosure - Income Taxes
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995605 - Disclosure - Defined Contribution Plan
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995615 - Disclosure - Restructuring Activities
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995625 - Disclosure - Net Loss per Share
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995635 - Disclosure - Related-Party Transactions
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995645 - Disclosure - Segment Information
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995655 - Disclosure - Summary of Significant Accounting Policies (Policies)
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995665 - Disclosure - Summary of Significant Accounting Policies (Tables)
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995675 - Disclosure - Fair Value Measurements (Tables)
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995685 - Disclosure - Cash Equivalents and Marketable Securities (Tables)
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995695 - Disclosure - Property and Equipment, Net (Tables)
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995705 - Disclosure - Additional Balance Sheet Detail (Tables)
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995715 - Disclosure - Common Stock (Tables)
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995725 - Disclosure - Stock-based Compensation Expense (Tables)
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995735 - Disclosure - Leases (Tables)
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995745 - Disclosure - Commitments and Contingencies (Tables)
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995755 - Disclosure - Income Taxes (Tables)
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995765 - Disclosure - Restructuring Activities (Tables)
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995775 - Disclosure - Net Loss per Share (Tables)
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995785 - Disclosure - Segment Information (Tables)
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995795 - Disclosure - Nature of the Business and Basis of Presentation - Additional Information (Details)
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995805 - Disclosure - Summary of Significant Accounting Policies - Schedule of the Estimated Useful Life of Related Asset (Details)
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995815 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Details)
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995825 - Disclosure - Fair Value Measurements - Summary of Financial Assets Measured at Fair Value on Recurring Basis and Level of Fair Value Hierarchy Utilized (Details)
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995835 - Disclosure - Fair Value Measurements - Additional Information (Details)
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995845 - Disclosure - Cash Equivalents and Marketable Securities - Summary of Marketable Securities (Details)
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995855 - Disclosure - Cash Equivalents and Marketable Securities - Additional Information (Details)
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995865 - Disclosure - Property and Equipment, Net - Schedule of Property and Equipment, Net (Details)
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995875 - Disclosure - Property and Equipment, Net - Additional Information (Details)
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995885 - Disclosure - Additional Balance Sheet Detail - Schedule of Prepaid Expenses and Other Current Assets (Details)
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995895 - Disclosure - Additional Balance Sheet Detail - Schedule of Accrued Expenses and Other Current Liabilities (Details)
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995905 - Disclosure - Additional Balance Sheet Detail - Additional Information (Details)
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995915 - Disclosure - Preferred Stock - Additional Information (Details)
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995925 - Disclosure - Common Stock - Additional Information (Details)
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995935 - Disclosure - Common Stock - Schedule of Potential Conversion of Preferred Stock and Future Issuance of Common Stock (Details)
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995945 - Disclosure - Stock-based Compensation Expense - Additional Information (Details)
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995955 - Disclosure - Stock-based Compensation Expense - Summary of Restricted Stock Activity under 2019 Plan and 2016 Plan (Details)
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995965 - Disclosure - Stock-based Compensation Expense - Summary of Stock Option Activity (Details)
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995975 - Disclosure - Stock-based Compensation Expense - Summary of Weighted Average Assumptions Used to Calculate Fair Value of Stock Option (Details)
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995985 - Disclosure - Stock-based Compensation Expense - Summary of Restricted Stock Activity outside of 2019 and 2016 Plan (Details)
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995995 - Disclosure - Stock-based Compensation Expense - Summary of Stock-Based Compensation Expense Recognized (Details)
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996005 - Disclosure - License and Collaboration Agreements - Additional Information (Details)
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996015 - Disclosure - Leases - Schedule of Future minimum lease payments (Details)
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996025 - Disclosure - Leases - Schedule of Future minimum lease payments (Details) 2
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996035 - Disclosure - Leases - Schedule of Minimum rental commitments under non-cancelable leases (Details)
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996045 - Disclosure - Leases (Additional Information) (Details)
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996055 - Disclosure - Commitments and Contingencies - Additional Information (Details)
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996065 - Disclosure - Commitments and Contingencies - Schedule of Future Minimum Lease Payments (Details)
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996075 - Disclosure - Commitments and Contingencies - Schedule of Future Minimum Lease Payments (Details One)
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996085 - Disclosure - Income Taxes - Schedule of Reconciliation of U.S. Federal Statutory Income Tax Rate (Details)
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996095 - Disclosure - Income Taxes - Schedule of Deferred Tax Assets and Liabilities (Details)
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996105 - Disclosure - Income Taxes - Additional Information (Details)
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996115 - Disclosure - Defined Contribution Plan - Additional Information (Details)
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996125 - Disclosure - Restructuring Activities - Schedule of Restructuring Charges (Details)
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996135 - Disclosure - Restructuring Activities (Additional Information) (Details)
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996145 - Disclosure - Net Loss per Share - Schedule of Antidilutive Securities Excluded from Calculation of Diluted Net Loss per Share Attributable to Common Stockholders (Details)
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996155 - Disclosure - Related-Party Transactions - Additional Information (Details)
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996165 - Disclosure - Segment Information - Schedule of Reportable Segment Revenue, Operating Expenses, and Net Loss (Details)
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Lessee, operating leases, allowance for normal leasehold improvements.
Lessee Operating Leases Allowance For Normal Leasehold Improvements
Lessee, operating leases, allowance for normal leasehold improvements
Increase in number of shares reserved for issuance, percent of common stock outstanding.
Increase In Number Of Shares Reserved For Issuance Percent Of Common Stock Outstanding
Increase in number of shares reserved for issuance, percent of common stock outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Weighted Average Grant Date Fair Value, Vested
Variable Lease, Payment
Variable Lease, Payment
Regulated Operation, Inventory [Table]
Public Utilities Inventory [Table]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures and Expirations in Period, Weighted Average Exercise Price
Weighted Average Exercise Price, Cancelled
Software Development [Member]
Software
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Preferred Stock, Shares Issued, Total
Preferred Stock, Shares Issued
Preferred stock, shares issued
Deferred revenue current and noncurrent.
Deferred Revenue Current And Noncurrent
Deferred revenue current and non-current
Operating Leases Future Minimum Payment Due in Three Years
Operating Leases Future Minimum Payment Due in Three Years
2027
Increase (Decrease) in Accounts Payable, Total
Increase (Decrease) in Accounts Payable
Accounts payable
Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]
Non-cash investing and financing activities:
Cash Exchange Related To Transaction
Cash Exchange Related To Transaction
Plan Name [Axis]
Plan Name
Capital Lease Obligations, Current
Capital lease obligation, current portion
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, 12 Months or Longer
Aggregate fair value of securities, unrealized loss position for more than 12 months
Equity [Abstract]
Entity Current Reporting Status
Entity Current Reporting Status
Other Commitment
Other Commitment, Total
Other Commitment
ProceedsFromWarrantExercises
Proceeds from Warrant Exercises
Clinical program
Clinical program
Clinical program | Segment
Operating Expenses [Abstract]
Operating expenses:
Fair Value, Inputs, Level 2 [Member]
Level 2
Deferred Tax Assets, Net of Valuation Allowance
Net deferred tax assets
Commitments and Contingencies Disclosure [Text Block]
Commitments and Contingencies
Contract Termination Date
Contract Termination Date
Contract termination date
Common Stock, Shares Authorized
Common stock, shares authorized
MASSACHUSETTS
Cambridge, Massachusetts
Temporary Equity, Par or Stated Value Per Share
Convertible preferred stock, share price
Effective Income Tax Rate Reconciliation Ownership Change Amount
Impact of ownership change
Effective Income Tax Rate Reconciliation Ownership Change Amount
Product and Service [Axis]
Research Development And Sales Arrangement Amount Received Upon Achievement Of Milestone
Research Development And Sales Arrangement Amount Received Upon Achievement Of Milestone
Document Fiscal Period Focus
Document Fiscal Period Focus
Entity Shell Company
Entity Shell Company
Share based compensation arrangement by share based payment award equity instruments other than options repurchased in period weighted average grant date fair value.
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Repurchased In Period Weighted Average Grant Date Fair Value
Weighted Average Grant Date Fair Value, Repurchased
Temporary Equity, Shares Outstanding
Convertible preferred stock, Ending balance, Shares
Convertible preferred stock, Beginning balance, Shares
Convertible preferred stock, share outstanding
Segment Reporting, Policy [Policy Text Block]
Segment Information
Cash and Cash Equivalents, at Carrying Value, Ending Balance
Cash and Cash Equivalents, at Carrying Value, Beginning Balance
Cash and Cash Equivalents, at Carrying Value, Total
Cash and Cash Equivalent
Cash and cash equivalents
Cybersecurity Risk Management, Strategy, and Governance [Abstract]
Common Stock, Shares, Issued, Total
Common Stock, Shares, Issued
Common stock, shares issued
Cybersecurity Risk Management Positions or Committees Responsible Report to Board [Flag]
Cybersecurity Risk Board of Directors Oversight [Text Block]
Asset Class [Domain]
Statement [Table]
Statement [Table]
MyoKardia Agreement [Member]
MyoKardia Agreement [Member]
MyoKardia Agreement
Restricted Cash, Noncurrent
Restricted cash
Interest Receivable
Interest income receivable
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted average grant date fair value
Number of Debt Securities, Continuous Unrealized Loss Position, Less than 12 Months
Number of Debt Securities, Continuous Unrealized Loss Position, Less than 12 Months
Number of debt securities, unrealized loss position, less than 12 months
Statement [Line Items]
Statement [Line Items]
Revenue from Contract with Customer [Policy Text Block]
Revenue Recognition
Entity Filer Category
Entity Filer Category
Deferred tax assets orphan drug credit carryforwards.
Deferred Tax Assets Orphan Drug Credit Carryforwards
Orphan drug credit carryforwards
Two thousand nineteen and two thousand sixteen stock incentive plan.
Two Thousand Nineteen And Two Thousand Sixteen Stock Incentive Plan [Member]
2019 Plan and 2016 Plan
Change in variable consideration constrained
Change In Variable Consideration Constrained
Change in variable consideration constrained.
Reimbursement Payment Recieved.
Reimbursement Payment Recieved
Reimbursement Payment Recieved
Liabilities and Equity
Total liabilities and stockholders’ equity
Accounting Standards Update and Change in Accounting Principle [Table Text Block]
Schedule of Accounting Standards Update and Change in Accounting Principle
Payments to Acquire Marketable Securities, Total
Payments to Acquire Marketable Securities
Purchases of marketable securities
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Weighted Average Exercise Price, Exercisable
Long-Lived Tangible Asset [Axis]
Long-Lived Tangible Asset
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Increase in valuation allowance
Cash equivalents and marketable securities accumulated gross unrealized gains before tax.
Cash Equivalents And Marketable Securities Accumulated Gross Unrealized Gains Before Tax
Total cash equivalents and marketable securities, Gross Unrealized Gains
Common Stock Warrants
Common Stock Warrants [Policy Text Block]
Common Stock Warrants [Policy Text Block]
Cybersecurity Risk Third Party Oversight and Identification Processes [Flag]
Cash and Cash Equivalents, Fair Value Disclosure
Cash equivalents
Cash equivalents, Fair Value
Payment for Prepaid Research Funding.
Payment For Prepaid Research Funding
Payment for prepaid research funding
Deferred Tax Assets, Valuation Allowance, Total
Deferred Tax Assets, Valuation Allowance
Valuation allowance
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
U.S. federal statutory tax rate
Share price
Shares Issued, Price Per Share
Shares issued, price per share
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Amount
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Amount, Total
Other permanent differences
Property Plant And Equipment Estimated Useful Lives
PropertyPlantAndEquipmentUsefulLives
PropertyPlantAndEquipmentUsefulLives
Cybersecurity Risk Management Third Party Engaged [Flag]
Documents Incorporated by Reference
Documents Incorporated by Reference [Text Block]
Effective Income Tax Rate Reconciliation, Percent
Effective income tax rate
Stock Option
Income Tax Jurisdiction [Axis]
Income Tax Authority
Geographical [Domain]
Geographical
Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]
Restricted Cash
Schedule of accrued expenses and other current liabilities.
Schedule Of Accrued Expenses And Other Current Liabilities Table [Text Block]
Schedule of Accrued Expenses and Other Current Liabilities
Costs Associated with Exit or Disposal Activity or Restructuring [Policy Text Block]
Restructuring Expenses
Reconciliation of Operating Profit (Loss) from Segments to Consolidated [Table Text Block]
Schedule of Reportable Segment Revenue, Operating Expenses, and Net Loss
Additional Paid in Capital, Common Stock, Ending Balance
Additional Paid in Capital, Common Stock, Beginning Balance
Additional Paid in Capital, Common Stock
Additional paid-in capital
Nature of business and basis of presentation.
Nature Of Business And Basis Of Presentation [Table]
Nature Of Business And Basis Of Presentation [Table]
Cash and cash equivalents accumulated gross unrealized gains before tax.
Cash And Cash Equivalents Accumulated Gross Unrealized Gains Before Tax
Cash equivalents, Gross unrealized Gains
Consulting services.
Consulting Services [Member]
Consulting Services
Significant Accounting Policies [Text Block]
Summary of Significant Accounting Policies
Property, Plant and Equipment [Line Items]
Property Plant And Equipment [Line Items]
Share Repurchase Program [Axis]
Share Repurchase Program
Off-balance sheet risk and concentrations of credit risk.
Off Balance Sheet Risk And Concentrations Of Credit Risk Policy Policy [Text Block]
Off-Balance Sheet Risk and Concentrations of Credit Risk
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Number of Shares, Granted
Mr Sapir [Member]
Mr Sapir [Member]
Mr. Sapir
Cybersecurity Risk Management, Strategy, and Governance [Table]
Katina Dorton [Member]
Katina Dorton [Member]
Katina Dorton
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Amount [Abstract]
Nontaxable or nondeductible items:
Pociredir
Pociredir [Member]
Pociredir [Member]
Effective Income Tax Rate Reconciliation, Stock Compensation Cancellations, Percent
Effective Income Tax Rate Reconciliation, Stock Compensation Cancellations, Percent
Stock compensation cancellations
Earnings Per Share, Basic, Total
Earnings Per Share, Basic
Net loss per share, Basic
Retirement Benefits [Text Block]
Defined Contribution Plan
Cash and cash equivalents accumulated gross unrealized losses before tax.
Cash And Cash Equivalents Accumulated Gross Unrealized Losses Before Tax
Cash equivalents, Gross unrealized Losses
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Number of Shares, Outstanding, Ending balance
Number of Shares, Outstanding, Beginning balance
Cash equivalents and marketable securities accumulated gross unrealized gains before tax.
Cash Equivalents And Marketable Securities Accumulated Gross Unrealized Loss Before Tax
Total cash equivalents and marketable securities, Gross Unrealized Losses
Interest Income (Expense), Nonoperating
Other income, net
Interest Income (Expense), Nonoperating, Total
Liabilities, Current
Total current liabilities
Increase (Decrease) in Accounts Receivable
Unbilled accounts receivable
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract]
Adjustments to reconcile net loss to net cash used in operating activities:
2026
Lessee, Operating Lease, Liability, to be Paid, Year Five
Grants outside of two thousand sixteen stock incentive plan and two thousand nineteen stock incentive plan.
Grants Outside Of Two Thousand Sixteen Stock Incentive Plan And Two Thousand Nineteen Stock Incentive Plan [Member]
Grants Outside of 2016 Stock Incentive Plan and 2019 Stock Incentive Plan
Domestic Tax Jurisdiction [Member]
Federal
Share Repurchase Program [Domain]
Share Repurchase Program
Tax credits:
Effective Income Tax Rate Reconciliation, Tax Credit, Percent [Abstract]
Accounting Standards Update [Axis]
Stockholders' Equity, Policy [Policy Text Block]
Fair Value of Common Stock and Series B Convertible Preferred Stock
2022 Stock Inducement Plan
Two Thousand And Twenty Two Inducement Stock Incentive Plan [Member]
Two Thousand And Twenty Two Inducement Stock Incentive Plan [Member]
Consolidation Items [Domain]
Deferred tax assets, capitalized research and development costs.
Deferred Tax Assets, Capitalized Research And Development Costs
Capitalized research and development costs
Research contract costs and accruals.
Research Contract Costs And Accruals Policy [Text Block]
Research Contract Costs and Accruals
Equity, Attributable to Parent [Abstract]
Stockholders’ equity:
Entity Small Business
Entity Small Business
Accumulated deficit
Retained Earnings (Accumulated Deficit), Ending Balance
Retained Earnings (Accumulated Deficit), Beginning Balance
Retained Earnings (Accumulated Deficit), Total
Retained Earnings (Accumulated Deficit)
Accumulated deficit
Accounting Standards Update 2016-02 [Member]
Accounting Standards Update 2016-02 [Member]
Other Commitments [Line Items]
Effective Income Tax Rate Reconciliation, Cross-Border Tax Effect, Amount
Effective Income Tax Rate Reconciliation, Cross-Border Tax Effect, Amount, Total
Effects of cross-border-tax laws
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Net proceeds of common stock
Proceeds from initial public offering of common stock, net of underwriting discounts and commissions
Proceeds from Issuance Initial Public Offering
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value
Total intrinsic value of stock options exercised
Issuance of Common Stock Pursuant to Pre-Funded Warrant Exercise Value
Issuance of Common Stock Pursuant to Pre-Funded Warrant Exercise Value
Issuance of common stock pursuant to pre-funded warrant exercise
Share-Based Payment Arrangement [Text Block]
Stock-based Compensation Expense
Capital Leases, Future Minimum Payments Due in Two Years
Future minimum lease payments, 2021
Organization, Consolidation and Presentation of Financial Statements [Abstract]
26 Landsdowne Street [Member]
26 Landsdowne Street [Member]
26 Landsdowne Street [Member]
Leases [Abstract]
Pre-Funded Warrants [Member]
Pre-Funded Warrants [Member]
Pre-funded warrants
Amendment Flag
Amendment Flag
Product and Service [Domain]
Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount
U.S. federal statutory tax rate
CAMP4 Agreement [Member]
CAMP4 Agreement [Member]
Camp4 Agreement
Earnings Per Share, Policy [Policy Text Block]
Net Loss Per Share
Liabilities and Equity [Abstract]
Liabilities and stockholders’ equity
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation
Net cash used in operating activities
Corporate Bonds
Corporate Bonds [Member]
Corporate bonds.
Common Stock [Member]
Common Stock
Accounting Standards Update and Change in Accounting Principle [Table]
Cybersecurity Risk Role of Management [Text Block]
Tax Credit Carryforward, Amount
Tax credit carryforwards
Defined Contribution Plan, Employer Discretionary Contribution Amount
Employer Discretionary Contribution Amount
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Weighted Average Exercise Price, Granted
2024
Lessee, Operating Lease, Liability, to be Paid, Year Three
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Accumulated depreciation
Less: accumulated depreciation
Debt Securities, Available-for-Sale [Line Items]
Schedule Of Available For Sale Securities [Line Items]
Prepaid research funding payment received.
Prepaid Research Funding Payment Received
Prepaid research funding payment received
Government Agency Securities [Member]
Government Agency Securities [Member]
Government agency securities
Patent cost.
Patent Cost Policy [Text Block]
Patent-Related Costs
Entity Address, Address Line One
Entity Address, Address Line One
Deferred Tax Liabilities, Gross, Total
Deferred Tax Liabilities, Gross
Deferred tax liability
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Weighted Average Assumptions Used to Calculate Fair Value of Stock Option
Fair Value Hierarchy and NAV [Axis]
Fair Value Hierarchy and NAV
Earnings Per Share [Abstract]
Income Tax, Policy [Policy Text Block]
Income Taxes
Loss Contingency Accrual, Ending Balance
Loss Contingency Accrual, Beginning Balance
Loss Contingency Accrual
Accrued liabilities for indemnification agreements
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Flag]
Supplemental Cash Flow Information [Abstract]
Supplemental cash flow information
Alex C Sapir [Member]
Alex C Sapir [Member]
Alex C. Sapir
Office and laboratory space
Office and laboratory space
Office and laboratory space
Operating Lease, Right-of-Use Asset
Operating lease right-of-use assets
Deferred Tax Assets, Gross
Gross deferred tax assets
Cybersecurity Risk Board Committee or Subcommittee Responsible for Oversight [Text Block]
Gross proceeds threshold of automatic conversion of preferred stock to common stock.
Gross Proceeds Threshold Of Automatic Conversion Of Preferred Stock To Common Stock
Gross proceeds threshold of automatic conversion of preferred stock to common stock
Document Type
Document Type
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Entity Central Index Key
Entity Central Index Key
Proceeds from maturity of marketable securities.
Proceeds From Maturity Of Marketable Securities
Maturities of marketable securities
Investments, Debt and Equity Securities [Abstract]
Cybersecurity Risk Process for Informing Board Committee or Subcommittee Responsible for Oversight [Text Block]
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Including Exchange Rate Effect and Discontinued Operation
Net increase in cash, cash equivalents and restricted cash
Subsequent Event Type [Domain]
Subsequent Event Type
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Antidilutive securities excluded from calculation of diluted net loss per share
Balance Sheet Related Disclosures [Abstract]
Common Stock, Par or Stated Value Per Share
Common stock, par value
Common stock, par value
Accounting Standards Update [Domain]
Security Deposit
Security Deposit
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Weighted Average Remaining Contractual Term (in years), Outstanding
Contractual term
Debt Securities, Available-for-Sale, Amortized Cost
Marketable securities, Amortized Cost
Debt Securities, Available-for-sale, Total
Debt Securities, Available-for-Sale
Marketable securities
Marketable securities, Fair Value
Indemnification Agreement [Member]
Indemnification Agreement
Defined Contribution Plan Name
Defined Contribution Plan Name
Defined contribution plan name
Document Financial Statement Error Correction [Flag]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Number of Shares, Exercised
Trd Arr Modified Date
Trd Arr Modified Date
Modified Date
Marketable Securities, Total
Marketable Securities
Marketable securities
Stock Issued During Period, Value, Restricted Stock Award, Gross
Vesting of restricted stock awards
Current Fiscal Year End Date
Current Fiscal Year End Date
Series b stock purchase agreement.
Series B Stock Purchase Agreement [Member]
Series B Stock Purchase Agreement
Entity Address, State or Province
Entity Address, State or Province
Number of Shares, Unvested, Ending balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Number of Shares, Unvested, Beginning balance
Increase (Decrease) in Accounts and Other Receivables
Accounts receivable
Preferred Stock, Shares Outstanding, Ending Balance
Preferred Stock, Shares Outstanding, Beginning Balance
Preferred Stock, Shares Outstanding
Preferred stock, shares outstanding
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Comprehensive loss
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax
Marketable securities, Gross Unrealized Gains
Research and Development Expense, Policy [Policy Text Block]
Research and Development Expense
Common Stock, Capital Shares Reserved for Future Issuance
Shares reserved for future issuance
Shares reserved for future issuance under the 2022 Inducement Stock Incentive Plan
Grants under two thousand nineteen employee stock purchase plan.
Grants Under Two Thousand Nineteen Employee Stock Purchase Plan [Member]
2019 Employee Stock Purchase Plan
Geographical [Axis]
Geographical
Thereafter
Thereafter
Thereafter
Marketable Securities, Current, Total
Marketable Securities, Current
Marketable securities
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Amount
State and local income tax, net of federal income tax effect
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Summary of Stock-Based Compensation Expense Recognized
Comprehensive Loss
Comprehensive Income, Policy [Policy Text Block]
125 Sidney Street [Member]
125 Sidney Street [Member]
125 Sidney Street [Member]
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Schedule of Deferred Tax Assets and Liabilities
Number of directors stockholders are entitled to elect.
Number Of Directors Stockholders Are Entitled To Elect
Number of directors stockholders are entitled to elect
Collaborative Arrangement Disclosure [Text Block]
License and Collaboration Agreements
Other Comprehensive Income (Loss), Net of Tax [Abstract]
Other comprehensive gain:
Subsequent Event [Member]
Subsequent Event
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Greater than 12 Months
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Greater than 12 Months
Debt Securities, Available-for-Sale
Marketable Securities, Policy [Policy Text Block]
Marketable Securities
Property, Plant and Equipment [Abstract]
Proceeds from sale of marketable securities.
Proceeds From Sale Of Marketable Securities
Sale of marketable securities
Deferred Tax Assets, Tax Credit Carryforwards, Research
Research and development credit carryforwards
Other Assets, Noncurrent, Total
Other Assets, Noncurrent
Other assets
Antidilutive Securities [Axis]
Antidilutive Securities
Commitments and contingencies.
Commitments And Contingencies [Table]
Commitments And Contingencies [Table]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Abstract]
Other Commitments [Domain]
Other Commitments
State and Local Jurisdiction [Member]
State
Related Party Transaction [Axis]
Related Party Transaction
Increase Decrease in Research and Development Expenses
Increase Decrease in Research and Development Expenses
Milestone Payment for certain Other Identified Targets.
Milestone Payment For Certain Other Identified Targets
Milestone payment for certain other identified targets
AOCI Attributable to Parent [Member]
Accumulated other comprehensive loss
ATM Offering
At-The-Market Offering.
At The Market Offering [Member]
At-The-Market Offering
pre funded warrant acquire
pre funded warrant acquire
PreFundedWarrantAcquire
Effective Income Tax Rate Reconciliation Federal Orphan Drug Credits Amount
Effective Income Tax Rate Reconciliation Federal Orphan Drug Credits Amount
Federal orphan drug credits
Other Commitments [Table]
Lessee, Operating Lease, Option to Extend
Operating lease option to extend description
Nature of business and basis of presentation.
Nature Of Business And Basis Of Presentation [Line Items]
Nature Of Business And Basis Of Presentation [Line Items]
Preferred Stock, Value, Issued, Ending Balance
Preferred Stock, Value, Issued, Beginning Balance
Preferred Stock, Value, Issued, Total
Preferred Stock, Value, Issued
Preferred stock, $0.001 par value; 5,000,000 shares authorized; no shares issued or outstanding
Ownership Limitation Description
Ownership Limitation Description
OwnershipLimitationDescription
Minimum [Member]
Minimum [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted Average Grant Date Fair Value, Granted
Financial Instrument [Axis]
Assets, Current [Abstract]
Current assets:
Reconciliation of Operating Profit (Loss) from Segments to Consolidated [Table]
Temporary equity, dividends declared
Temporary Equity Dividends Declared
Temporary equity dividends declared
Segment Reporting [Abstract]
Fair Value, Assets Measured on Recurring Basis [Table Text Block]
Summary of Financial Assets Measured at Fair Value on Recurring Basis and Level of Fair Value Hierarchy Classification
Liabilities, Current [Abstract]
Current liabilities:
Restructuring and Related Activities Disclosure [Text Block]
Restructuring Activities
Unrecognized Tax Benefits, Interest on Income Taxes Accrued
Accrued interest related to uncertain tax positions
Preferred Stock, Convertible, Terms
Convertible preferred stock, terms of conversion
Related Party Transactions [Abstract]
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals, Accrued Liabilities
Accrued expenses and other
Shares, Outstanding
Ending balance, Shares
Beginning balance, Shares
Operating Loss Carryforwards, Total
Operating Loss Carryforwards
Net operating loss carryforwards
Lessee, Operating Lease, Renewal Term
Operating lease renewal term
Milestone Payment For Certain Identified Targets.
Milestone Payment For Certain Identified Targets
Milestone payment for certain identified targets
Commitments and Contingencies
Commitments and contingencies (Note 12)
Lessee, Leases [Policy Text Block]
Leases
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Weighted Average Grant Date Fair Value, Unvested, Ending balance
Weighted Average Grant Date Fair Value, Unvested, Beginning balance
Repayments of Long-Term Capital Lease Obligations
Principal payments on capital lease obligations
Represents schedule of prepaid expenses and other current assets.
Schedule Of Prepaid Expenses And Other Current Assets Table [Text Block]
Schedule of Prepaid Expenses and Other Current Assets
General and Administrative Expense [Member]
General and Administrative
Percentage of commission on sales price per share
Commission as percentage of sale price per share.
Percentage Of Commission On Gross Sales Price Per Share
Total lease liability
Operating Lease, Liability
Total lease liability
Auditor Firm ID
Estimated useful life of asset.
Estimated Useful Life Of Asset Table [Text Block]
Schedule of Estimated Useful Life of Asset
Stockholders' Equity, Reverse Stock Split
Reverse stock split
Lessee operating lease written notice period to extend additional lease term.
Lessee Operating Lease Written Notice Period To Extend Additional Lease Term
Written notice period to extend additional lease term
Commitments and contingencies.
Commitments And Contingencies [Line Items]
Commitments And Contingencies [Line Items]
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Changes in valuation allowances
Pre Funded Warrants Acquire
Pre Funded Warrants Acquire
Schedule of Restructuring Reserve by Type of Cost [Table Text Block]
Schedule of Restructuring Charges
Increase in common stock capital shares reserved for future issuance.
Increase In Common Stock Capital Shares Reserved For Future Issuance
Increase in number of shares reserved for issuance (shares)
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Net loss
Cybersecurity Risk Management Positions or Committees Responsible [Text Block]
Weighted Average Number of Shares Outstanding, Basic, Total
Weighted Average Number of Shares Outstanding, Basic
Weighted-average common shares outstanding, Basic
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Aggregate Intrinsic Value, Exercisable
Leases, Operating [Abstract]
Number of common stock voting rights.
Number Of Common Stock Voting Rights
Number of common stock voting rights
Other
Effective Income Tax Rate Reconciliation, Other Reconciling Items, Amount
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Schedule of Reconciliation of U.S. Federal Statutory Income Tax Rate
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Public Utilities, Inventory [Line Items]
Public Utilities Inventory [Line Items]
Schedule of Operating Leased Assets [Table]
Long-Lived Tangible Asset [Domain]
Long-Lived Tangible Asset
Cybersecurity Risk Process for Informing Management or Committees Responsible [Text Block]
Proceeds from issuance of common stock in connection with private placement, net of placement agent fees and offering costs
Net proceeds of after deducting offering costs
Proceeds from Issuance of Private Placement
Operating Leases, Future Minimum Payment Due in Four Years
Operating Leases, Future Minimum Payment Due in Four Years
2028
Related Party Transactions Disclosure [Text Block]
Related-Party Transactions
APIC, Share-based Payment Arrangement, Increase for Cost Recognition, Total
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Stock-based compensation expense
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount
Changes in valuation allowances
Beginning balance
Equity, Attributable to Parent
Ending balance
Total stockholders’ equity
Preferred Stock, Par or Stated Value Per Share
Preferred stock, par value
Lessee, Operating Lease, Existence of Option to Extend [true false]
Operating lease option to extend
Statement of Stockholders' Equity [Abstract]
Series A Preferred Stock [Member]
Series A Preferred Stock
Use of Estimates, Policy [Policy Text Block]
Use of Estimates
Collaborative Arrangement
Collaborative Arrangement [Member]
Leaseholds and Leasehold Improvements [Member]
Capital Leases
Leasehold Improvements [Member]
Leasehold Improvements
Fair Value Disclosures [Text Block]
Fair Value Measurements
Prepaid expenses.
Prepaid Expenses
Prepaid expenses
Other Assets, Current
Other
Effective Income Tax Rate Reconciliation Stock Compensation Cancellations Amount
Effective Income Tax Rate Reconciliation Stock Compensation Cancellations Amount
Stock compensation cancellations
Minimum percentage of shareholders vote or written consent required for automatic conversion.
Minimum Percentage Of Shareholders Vote Or Written Consent Required For Automatic Conversion
Minimum percentage of shareholders vote or written consent required for automatic conversion
Plan Name [Domain]
Plan Name
Increase (Decrease) in Other Operating Assets, Total
Increase (Decrease) in Other Operating Assets
Other assets
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Text Block]
Tax credit carryforward expiration year.
Tax Credit Carryforward Expiration Year
Tax credit carryforwards, Expiration year
Cybersecurity Risk Management Expertise of Management Responsible [Text Block]
Income taxes disclosure.
Income Taxes Disclosure [Line Items]
Income Taxes Disclosure [Line Items]
Range of tiered royalties on net sales.
Range Of Tiered Royalties On Net Sales
Range of tiered royalties on net sales
Lab equipment.
Lab Equipment [Member]
Lab Equipment
Related and Nonrelated Parties [Axis]
Related Party
Property, Plant and Equipment, Policy [Policy Text Block]
Property and Equipment
Entity Address, City or Town
Entity Address, City or Town
Other Commitments [Axis]
Other Commitments
Operating Loss Carryforwards, Valuation Allowance, Total
Operating Loss Carryforwards, Valuation Allowance
Increase in valuation allowance
Third Rock Ventures LLC.
Third Rock Ventures L L C [Member]
TRV
Security Exchange Name
Security Exchange Name
Property, Plant and Equipment, Gross, Ending Balance
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross, Total
Property, Plant and Equipment, Gross
Total property and equipment
Total property and equipment, gross
Deferred Tax Assets, Operating lease Liabilities
Deferred Tax Assets, Operating lease Liabilities
Operating lease liability
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name
Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Percent
Foreign tax effects
Loss Contingency, Loss in Period
Expenses incurred for legal proceedings
Deferred Tax Assets, Goodwill and Intangible Assets
Intangible assets
Cumulative catch-up adjustment
Cumulative Catch Up Adjustment
Cumulative Catch-Up Adjustment
Statistical Measurement [Domain]
Statistical Measurement
Assets, Current
Total current assets
Officers' compensation
Effective Income Tax Rate Reconciliation Officers Compensation Percent
Effective income tax rate reconciliation officers compensation percent.
Stock-based compensation expenses
Share-Based Payment Arrangement, Expense
Document Period End Date
Document Period End Date
Fair Value Hierarchy and NAV [Domain]
Fair Value Hierarchy and NAV
ICFR Auditor Attestation Flag
ICFR Auditor Attestation Flag
Issuance of Common Stock Pursuant to Pre-Funded Warrant Exercise Shares
Issuance of common stock pursuant to pre-funded warrant exercise shares
Issuance of Common Stock Pursuant to Pre-Funded Warrant Exercise Shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Number of Shares, Exercisable
Offering costs unpaid at end of period
Offering Costs Unpaid
Offering Costs Unpaid
Statement of Financial Position [Abstract]
Restricted Stock Units (RSUs) [Member]
Restricted Stock Units
Loss Contingency Nature [Axis]
Loss Contingency Nature
Stock Issued During Period, Shares, Purchase of Assets
Shares issued for asset acquisition
Accrued liabilities and other current liabilities.
Accrued Liabilities And Other Current Liabilities
Accrued expenses and other current liabilities
Total accrued expenses and other current liabilities
Loss Contingency, Nature [Domain]
Loss Contingency, Nature
Antidilutive Security, Excluded EPS Calculation [Table]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Class of Stock [Axis]
Class of Stock
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]
Cash and cash equivalents amortized cost.
Cash And Cash Equivalents Amortized Cost
Cash equivalents, Amortized Cost
Income taxes disclosure.
Income Taxes Disclosure [Table]
Income Taxes Disclosure [Table]
Cybersecurity Risk Management, Strategy, and Governance [Line Items]
GSK agreement.
G S K Agreement [Member]
GSK Agreement
G S K Agreement [Member]
Effective Income Tax Rate Reconciliation, Change in Enacted Tax Rate, Percent
Effects of changes in tax laws or rates enacted in the current period
Liabilities
Total liabilities
Lessee, Operating Lease, Discount Rate
Financial Instruments [Domain]
Restructuring and Related Cost, Incurred Cost
Restructuring expenses
Increase (Decrease) in Deferred Revenue
Deferred revenue
Dividends, Total
Dividends
Dividends declared or paid
Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Amount
Foreign tax effects
Weighted Average Remaining Contractual Term (in years), Outstanding, Beginning Balance
Weighted Average Remaining Contractual Term (in years), Outstanding, Beginning Balance
2023
Lessee, Operating Lease, Liability, to be Paid, Year Two
Restricted Stock [Member]
Restricted Stock
Restricted stock units
Weighted Average Number of Shares Outstanding, Diluted, Total
Weighted Average Number of Shares Outstanding, Diluted
Weighted-average common shares outstanding, Diluted
Entity File Number
Entity File Number
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Unrealized gain on marketable securities
Effective Income Tax Rate Reconciliation, Other Reconciling Items, Percent, Total
Effective Income Tax Rate Reconciliation, Other Reconciling Items, Percent
Other
Recently adopted accounting pronouncements.
Recently Adopted Accounting Pronouncements Policy [Text Block]
Recently Adopted Accounting Pronouncements
Cover
Cover [Abstract]
Other Expenses
Other allocated expenses
Prepaid Expense and Other Assets, Current
Prepaid expenses and other current assets
Total prepaid expenses and other current assets
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Number of Shares, Cancelled
Number of Shares, Cancelled
Supplemental Balance Sheet Disclosures [Text Block]
Additional Balance Sheet Detail
US Treasury Securities [Member]
U S Treasury Securities [Member]
Number of Operating Segments
Number of operating segment
Area of properties held under operating leases.
Area Of Properties Held Under Operating Leases
Square feet of office and laboratory space leased under operating lease
Sale of Stock [Domain]
Sale of Stock
Segment Reporting Disclosure [Text Block]
Segment Information
General and Administrative Expense, Total
General and Administrative Expense
General and administrative
Series B Preferred Stock [Member]
Series B Convertible Preferred Stock
Revenue from Contract with Customer, Including Assessed Tax
Collaboration revenue
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures and Expirations in Period, Total
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures and Expirations in Period
Number of Shares, Cancelled
Operating Leased Assets [Line Items]
Operating Leased Assets [Line Items]
Lessor, Operating Lease, Renewal Term
Lessor, Operating Lease, Renewal Term
Changes in unrecognized tax benefits
Unrecognized Tax Benefits Percent
Unrecognized Tax Benefits Percent
Accrued research and development expenses.
Accrued Research And Development Expenses
External research and development
2022 Inducement Stock Incentive Plan
TwoThousandTwentyTwoInducementStockIncentivePlan [Member]
TwoThousandTwentyTwoInducementStockIncentivePlan [Member]
Effective Income Tax Rate Reconciliation, Change in Enacted Tax Rate, Amount
Effects of changes in tax laws or rates enacted in the current period
Operating Lease, Expense
Operating Lease, Expense
Operating Leases, Rent Expense, Net [Abstract]
Restructuring Charges, Total
Restructuring Charges
Restructuring Charges
Property, Plant and Equipment, Useful Life
Estimated useful life of asset
Recent Accounting Pronouncements-Adopted
New Accounting Pronouncements, Policy [Policy Text Block]
Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block]
Schedule of Future Minimum Lease Payments
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Vesting period
Series A convertible preferred stock.
Series A Convertible Preferred Stock [Member]
Series A Convertible Preferred Stock
Unrecognized Tax Benefits, Period Increase (Decrease)
Unrecognized Tax Benefits, Period Increase (Decrease), Total
Changes in unrecognized tax benefits
Depreciation, Total
Depreciation
Depreciation expense
Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense, Total
Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense
Penalties and interest expense related to income taxes
Lessee, Operating Lease, Term of Contract
Operating lease term
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Payments
Expected dividend yield
Common Stock, Shares, Outstanding, Ending Balance
Common Stock, Shares, Outstanding, Beginning Balance
Common Stock, Shares, Outstanding
Common stock, shares outstanding
Operating Lease, Liability, Current
Operating lease liability, current
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Pre-Development Candidate Expenses [Member]
Pre-Development Candidate Expenses [Member]
Pre-Development Candidate Expenses
Cybersecurity Risk Management Processes Integrated [Flag]
Document Transition Report
Document Transition Report
Deferred Tax Assets, Net
Net deferred tax assets
Operating Expenses
Total operating expenses
Operating Expenses
Research and Development Expense, Total
Research and Development Expense
Research and development
Asset Impairment Charges, Total
Asset Impairment Charges
Impairment losses on long-lived assets
Asset Impairment Charges
Lessee, Operating Leases [Text Block]
Leases
Convertible Preferred Stock [Member]
Convertible Preferred Stock
Statement of Cash Flows [Abstract]
Stock Issued During Period, Value, New Issues
Issuance of common stock, net of issuance costs
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Summary of Stock Option Activity
License Agreements
The entire disclosure for asset acquisition.
Asset Acquisition Disclosure [Text Block]
Stock-based compensation
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Percent
Equity [Text Block]
Common Stock
Earnings Per Share [Text Block]
Net Loss per Share
Temporary Equity [Line Items]
Temporary Equity [Line Items]
Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block]
Summary of Restricted Stock Activity
Computer Equipment [Member]
Computer Equipment
Cybersecurity Risk Management Processes Integrated [Text Block]
Net loss
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Aggregate Intrinsic Value, Outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Expected dividend yield
Non-refundable upfront payments received.
Non Refundable Upfront Payments Received
Non refundable upfront payment received
Preferred Stock, Dividend Rate, Per-Dollar-Amount
Preferred stock, dividend per share
Assets [Abstract]
Assets
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Risk-free interest rate
Construction in Process
Construction in Progress [Member]
Increase (Decrease) in Prepaid Expense and Other Assets, Total
Increase (Decrease) in Prepaid Expense and Other Assets
Prepaid expenses and other current assets
Restructuring and Related Activities [Abstract]
Document Fiscal Year Focus
Document Fiscal Year Focus
Alan Ezekowitz [Member]
Alan Ezekowitz [Member]
Alan Ezekowitz
Less: imputed interest
Less: imputed interest
Less: imputed interest
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract]
Investing activities
Retirement Benefits [Abstract]
Accounts Payable, Current, Total
Accounts Payable, Current
Accounts payable
Research and Development Expense [Member]
Research and Development
Member stands for legal proceedings.
Legal Proceedings [Member]
Legal Proceedings
Deferred Revenue
Deferred Revenue, Total
Issuance of Series B convertible preferred stock in connection with asset acquisition, net of issuance costs, Shares
Temporary equity, stock issued during period, shares, new issues.
Temporary Equity Stock Issued During Period Shares New Issues
Transaction Type [Axis]
Transaction Type
Research Tax Credit Carryforward [Member]
Research and Development
Components of Deferred Tax Assets [Abstract]
Deferred tax assets:
Cash equivalents and marketable securities fair value disclosure.
Cash Equivalents And Marketable Securities Fair Value Disclosure
Total cash equivalents and marketable securities, Fair Value
Temporary Equity Disclosure [Abstract]
Fair Value Disclosures [Abstract]
Commitments and Contingencies Disclosure [Abstract]
2022
Lessee, Operating Lease, Liability, to be Paid, Year One
Operating Leases, Rent Expense, Total
Operating Leases, Rent Expense
Rent expense
Share based compensation arrangement by share based payment award equity instruments other than options repurchased in period.
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Repurchased In Period
Number of Shares, Repurchased
Specified clinical and regulatory milestones phase two clinical trial
Clinical And Regulatory Milestone Payables Upon Phase Two Clinical Trial
Clinical and regulatory milestone payables upon phase two clinical trial.
Thereafter
Lessee, Operating Lease, Liability, to be Paid, after Year Five
Share-Based Payment Arrangement [Abstract]
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount
Unrecognized stock-based compensation expense
Assets, Fair Value Disclosure
Total
Assets, Fair Value Disclosure, Total
Sale of Stock [Axis]
Sale of Stock
Officers' compensation
Effective Income Tax Rate Reconciliation Officers Compensation Amount
Effective Income Tax Rate Reconciliation Officers Compensation Amount
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation
Net cash provided by investing activities
Private Placement [Member]
Private Placement
Title of 12(b) Security
Title of 12(b) Security
Stock-based compensation
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Amount
Issuance of Pre-Funded Warrants in Exchange for Common Stock Value
Issuance of Pre-Funded Warrants in Exchange for Common Stock Value
Issuance of pre-funded warrants in exchange for common stock, value
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Weighted Average Grant Date Fair Value, Cancelled
Money Market Funds [Member]
Money Market Funds
Related and Nonrelated Parties [Domain]
Related Party
Income Tax Disclosure [Text Block]
Income Taxes
Issuance of pre-funded warrants in exchange for common stock, Shares
Issuance of Pre-Funded Warrants in Exchange for Common Stock Shares
Issuance of Pre-Funded Warrants in Exchange for Common Stock Shares
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table]
Temporary Equity, Shares Issued
Convertible preferred stock, share issued
Weighted Average Remaining Contractual Term (in years), Outstanding, Ending balance
Weighted Average Remaining Contractual Term (in years), Outstanding, Ending balance
Other Liabilities, Noncurrent, Total
Other Liabilities, Noncurrent
Other liabilities, excluding current portion
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract]
Changes in operating assets and liabilities:
Workforce Plan Of Company Description
Workforce Plan Of Company Description
Workforce Plan Of Company Description
Property, Plant and Equipment [Table Text Block]
Schedule of Property and Equipment, Net
Letters of Credit Outstanding, Amount
Letters of credit
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Weighted Average Exercise Price, Outstanding, Ending balance
Weighted Average Exercise Price, Outstanding, Beginning balance
Preferred Stock [Text Block]
Preferred Stock
Operating Leases, Future Minimum Payments Due, Fiscal Year Maturity [Abstract]
Income Tax Disclosure [Abstract]
Fair Value, Recurring and Nonrecurring [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Additional Paid-in Capital [Member]
Additional Paid-In Capital
Effective income tax rate reconciliation, ownership change, percent.
Effective Income Tax Rate Reconciliation, Ownership Change, Percent
Impact of ownership change
Increase (Decrease) in Accrued Liabilities and Other Operating Liabilities
Accrued expenses and other liabilities
Aggregate Restructuring Charges
Aggregate Restructuring Charges
Aggregate Restructuring Charges
Measurement Frequency [Domain]
Measurement Frequency
Statement of Income Location, Balance [Axis]
Income Statement Location
Trading Symbol
Trading Symbol
Property, Plant and Equipment Disclosure [Text Block]
Property and Equipment, Net
Open Tax Year
Open tax year
Related Party Transaction [Table]
Schedule Of Related Party Transactions By Related Party [Table]
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent, Total
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent
Other permanent differences
Subsequent Event Type [Axis]
Subsequent Event Type
Employee-related Liabilities, Current, Total
Employee-related Liabilities, Current
Payroll and benefits
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract]
Financing activities
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Expected term (years)
Fair Value, Recurring [Member]
Recurring
Entity Ex Transition Period
Entity Ex Transition Period
Total minimum lease payments
Lessee, Operating Lease, Liability, to be Paid
Total minimum lease payments
Other than Temporary Impairment Losses, Investments, Total
Other than Temporary Impairment Losses, Investments
Securities with other-than-temporary impairment
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Percent
Federal research and development credits
Equity Components
Equity Components [Axis]
Accounts and Financing Receivable, after Allowance for Credit Loss, Total
Accounts and Financing Receivable, after Allowance for Credit Loss
Accounts and Financing Receivable, after Allowance for Credit Loss
Equity Component [Domain]
Equity Component
Worldwide net sales milestones.
Worldwide Net Sales Milestones [Member]
Worldwide Net Sales Milestones
Asset Class [Axis]
Asset Class
Schedule of Future Minimum Rental Payments for Operating Leases [Table Text Block]
Schedule of minimum rental commitments
Leasehold Improvements, Gross
Leasehold Improvements, Gross
Minimum percentage of outstanding shares of preferred stock for liquidation preference.
Minimum Percentage Of Outstanding Shares Of Preferred Stock For Liquidation Preference
Minimum percentage of outstanding shares of preferred stock for liquidation preference
Goodwill and Intangible Assets Disclosure [Abstract]
Amount of minimum lease payments for capital leases due after the second fiscal year, December 31, 2021.
Capital Leases Future Minimum Payments Due After Year Two
Future minimum lease payments, after 2021
Increase Decrease In Operating Lease Assets And Liabilities
Increase Decrease In Operating Lease Assets And Liabilities
Operating lease assets and liabilities
Operating lease assets and liabilities
Document Annual Report
Document Annual Report
IPO [Member]
IPO
Restructuring Charges, Statement of Income or Comprehensive Income [Extensible Enumeration]
Cash paid for operating lease liabilities
Cash paid for operating lease liabilities
Cash paid for operating lease liabilities
Collaborative Arrangement, Accounting Policy [Policy Text Block]
Collaborative Arrangements
Common Stock, Voting Rights
Common stock voting rights
Maximum [Member]
Maximum
Losmapimod [Member]
Losmapimod [Member]
Losmapimod
Schedule of Stock by Class [Table Text Block]
Schedule of Potential Conversion of Preferred Stock and Future Issuance of Common Stock
Statistical Measurement [Axis]
Statistical Measurement
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Weighted Average Exercise Price, Exercised
Common Stock, Value, Issued, Ending Balance
Common Stock, Value, Issued, Beginning Balance
Common Stock, Value, Issued, Total
Common Stock, Value, Issued
Common stock, $0.001 par value; 200,000,000 shares authorized; 66,578,891 and 53,968,303 shares issued and outstanding as of December 31, 2025 and December 31, 2024, respectively
Two thousand sixteen stock incentive plan.
Two Thousand Sixteen Stock Incentive Plan [Member]
2016 Stock Incentive Plan
Consolidation, Policy [Policy Text Block]
Principles of Consolidation
Operating Leases Future Minimum Payment Due in Two Years
Operating Leases Future Minimum Payment Due in Two Years
2026
Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract]
Comprehensive loss:
Stock Issued During Period, Value, Employee Benefit Plan
Issuance of common stock under employee benefit plans
Deferred Tax Assets, Operating Loss Carryforwards, Total
Deferred Tax Assets, Operating Loss Carryforwards
Net operating loss carryforwards
Cybersecurity Risk Management Processes for Assessing, Identifying, and Managing Threats [Text Block]
Tax Credit Carryforward [Axis]
Tax Credit Carryforward
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Impairment of Long-Lived Assets
Upfront payment.
Upfront Payment
Upfront payment
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent
State and local income tax, net of federal income tax effect
Entity Public Float
Entity Public Float
Operating loss carryforwards indefinitely.
Operating Loss Carryforwards Indefinitely
Net operating loss carryforwards indefinitely
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Expected stock price volatility
Preferred Stock, Shares Authorized
Preferred stock, shares authorized
Lessor, Operating Lease, Term of Contract
Lessor, Operating Lease, Term of Contract
Effective Income Tax Rate Reconciliation, Other Reconciling Items, Percent [Abstract]
Other adjustments:
Effective Income Tax Rate Reconciliation, Cross-Border Tax Effect, Percent
Effective Income Tax Rate Reconciliation, Cross-Border Tax Effect, Percent, Total
Effects of cross-border-tax laws
Related Party Transaction [Line Items]
Related Party Transaction [Line Items]
Grants under two thousand nineteen stock incentive plan.
Grants Under Two Thousand Nineteen Stock Incentive Plan [Member]
2019 Stock Incentive Plan
Employee Stock [Member]
2019 Employee Stock Purchase Plan
Entity Registrant Name
Entity Registrant Name
Preclinical milestone payment
Preclinical Milestone Payment
Preclinical Milestone Payment
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax
Marketable securities, Gross Unrealized Losses
Entity Voluntary Filers
Entity Voluntary Filers
Workforce reduction
Workforce reduction
Workforce reduction
Cybersecurity Risk Management Positions or Committees Responsible [Flag]
Effective income tax rate
Income Tax Expense (Benefit)
Income Tax Expense (Benefit), Total
Measurement Frequency [Axis]
Measurement Frequency
Proceeds from issuance of common stock under benefit plans, net
Proceeds from Issuance of Common Stock
Business Combination, Contingent Consideration, Type [Axis]
Contingent Consideration by Type
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Lessee, Operating Lease, Remaining Lease Term
Emerging growth company policy.
Emerging Growth Company Policy Policy [Text Block]
Emerging Growth Company Status
Preferred stock conversion price per share.
Preferred Stock Conversion Price Per Share
Preferred stock conversion price per share
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Accumulated Other Comprehensive Income (Loss), Net of Tax
Accumulated other comprehensive gain
Consolidation Items [Axis]
Payments for Restructuring
Amounts paid during the period
Amounts paid during the period
Restructuring Charges Paid
Payments to Acquire Property, Plant, and Equipment, Total
Payments to Acquire Property, Plant, and Equipment
Purchases of property and equipment
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Number of Shares, Granted
Series B convertible preferred stock.
Series B Convertible Preferred Stock [Member]
Series B Convertible Preferred Stock
Unbilled Accounts Receivable Related To Reimbursable Research And Development Cost
Unbilled accounts receivable related to reimbursable research and development cost.
Unbilled Accounts Receivable Related To Reimbursable Research And Development Cost
Temporary Equity, by Class of Stock [Table]
Temporary Equity By Class Of Stock [Table]
Assets
Total assets
Accrued Restructuring Charges
Accrued Restructuring Charges
Accrued restructuring charges Beginning
Accrued restructuring charges Ending
Property, Plant and Equipment [Table]
Schedule Of Property Plant And Equipment [Table]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Weighted Average Remaining Contractual Term (in years), Exercisable
Income Statement [Abstract]
Fair Value of Financial Instruments, Policy [Policy Text Block]
Fair Value of Financial Instruments
Share-Based Payment Arrangement [Policy Text Block]
Stock-Based Compensation
Cash Equivalents and Marketable Securities
Cash, Cash Equivalent, and Marketable Security [Text Block]
Research, development and sales arrangement aggregate amount receivable upon achievement of milestone.
Research Development And Sales Arrangement Aggregate Amount Receivable Upon Achievement Of Milestone
Aggregate amount receivable on achievement of milestone
Issuance of common stock, Shares
Stock Issued During Period, Shares, New Issues
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Number of Shares, Vested
Earnings Per Share, Diluted, Total
Earnings Per Share, Diluted
Net loss per share, diluted
Operating Segments [Member]
Dividends, Common Stock, Total
Dividends, Common Stock
Common stock dividends declared
City Area Code
City Area Code
Other Comprehensive Income (Loss), Net of Tax
Total other comprehensive gain
Auditor Name
Accrued restricted stock liability, current.
Accrued Restricted Stock Liability Current
Restricted stock liability, current portion
Fair value transfers between levels.
Fair Value Transfers Between Levels
Fair value transfers between levels
Federal research and development credits
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Amount
Effective income tax rate reconciliation federal orphan drug credits.
Effective Income Tax Rate Reconciliation Federal Orphan Drug Credits
Federal orphan drug credits
Cash equivalents and marketable securities amortized cost basis.
Cash Equivalents And Marketable Securities Amortized Cost Basis
Total cash equivalents and marketable securities, Amortized Cost
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Aggregate Intrinsic Value, Vested
Aggregate intrinsic value of restricted stock awards vested
The cash inflow associated with the amount received from entity's secondary offering of stock to the public.
Proceeds from Issuance of Common Stock in Connection with Follow-on Offering
Proceeds from issuance of common stock and pre-funded warrants in connection with public offerings, net of issuance costs
Stock Issued During Period, Shares, Restricted Stock Award, Gross
Vesting of restricted stock awards, Shares
Shares reserved for vesting of restricted stock units
Lease Expiration Date
Operating lease end date
Clinical and regulatory milestones.
Clinical And Regulatory Milestones [Member]
Clinical and Regulatory Milestones
Cash and Cash Equivalents, Policy [Policy Text Block]
Cash and Cash Equivalents
Clinical and regulatory milestone payables.
Clinical And Regulatory Milestone Payables
Specified clinical and regulatory milestones
Property, Plant and Equipment, Net, Ending Balance
Property, Plant and Equipment, Net, Beginning Balance
Property, Plant and Equipment, Net
Property and equipment, net
Property and equipment, net
ASC 840 [Member]
ASC 840 member.
ASC 840 [Member]
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Including Discontinued Operation
Cash, cash equivalents, and restricted cash, end of period
Cash, cash equivalents, and restricted cash, beginning of period
Total cash, cash equivalents, and restricted cash
Corporate Bond Securities [Member]
Corporate Bonds
Operating Income (Loss)
Loss from operations
Loss from operations
Two thousand nineteen stock incentive plan.
Two Thousand Nineteen Stock Incentive Plan [Member]
2019 Stock Incentive Plan
Retained Earnings [Member]
Accumulated Deficit
Business Combination, Contingent Consideration, Type [Domain]
Contingent Consideration Type
Stock Issued During Period, Shares, Employee Benefit Plan
Issuance of common stock under employee benefit plans, Shares
Transaction [Domain]
Transaction
Employee Benefits and Share-Based Compensation
Employee compensation expenses (excluding stock-based compensation expenses)
Share-based Payment Arrangement, Noncash Expense, Total
Share-Based Payment Arrangement, Noncash Expense
Stock-based compensation expense
Offering costs
Payments of Stock Issuance Costs
Prepaid sign-on bonuses subject to vesting provisions.
Prepaid Sign On Bonuses Subject To Vesting Provisions
Prepaid sign-on bonuses subject to vesting provisions
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Less than 12 Months
Aggregate fair value of securities, unrealized loss position for less than 12 months
Operating Lease, Liability, Noncurrent
Operating lease liability, excluding current portion
Fair Value, Inputs, Level 1 [Member]
Level 1
Class of Stock [Line Items]
Class Of Stock [Line Items]
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation
Net cash provided by financing activities
Auditor Location
Development and Regulatory Milestone Payments
Development and Regulatory Milestone Payments
Development and regulatory milestone payments
Marketable Securities [Table Text Block]
Summary of Marketable Securities
Rule 10b51 Arr Modified [Flag]
Rule 10b51 Arr Modified [Flag]
Rule 10b5-1 Arrangement Modified
Member stands for commitment for office and laboratory space lease of current corporate headquarters.
Commitment For Office And Laboratory Space Lease Of Current Corporate Headquarters [Member]
Commitment for Office and Laboratory Space Lease of Current Corporate Headquarters
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Schedule of Antidilutive Securities Excluded from Calculation of Diluted Net Loss per Share Attributable to Common Stockholders
Income Tax Jurisdiction [Domain]
Income Tax Authority
Debt Securities, Available-for-Sale [Table]
Debt Securities Available For Sale [Table]
Entity Interactive Data Current
Entity Interactive Data Current
Sales milestone.
Sales Milestone
Specified sales milestone
Statement of Income Location, Balance [Domain]
Income Statement Location
RA Capital [Member]
RA Capital [Member]
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract]
Operating activities
Furniture and Fixtures [Member]
Furniture and Fixtures
Convertible Preferred Stock, Shares Issued upon Conversion
Number of preferred stock converted into common stock
Accretion (Amortization) of Discounts and Premiums, Investments
Net accretion of discounts on marketable securities
Annual Taxable Income
Annual Taxable Income
Annual taxable income
Unbilled Receivables, Current
Unbilled accounts receivable
Unrecognized Tax Benefits, Income Tax Penalties Accrued
Accrued penalties related to uncertain tax positions
New Accounting Pronouncements To Be Adopted, Policy [Policy Text Block]
New Accounting Pronouncements To Be Adopted, Policy [Policy Text Block]
Recent Accounting Pronouncements - To Be Adopted
Stock Issued During Period, Shares, Issued for Services
Common stock shares issued in exchange for services
Entity Tax Identification Number
Entity Tax Identification Number
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]
Nature of the Business and Basis of Presentation
Operating loss carryforwards expiration year.
Operating Loss Carryforwards Expiration Year
Net operating loss carryforwards expiration beginning year
Local Phone Number
Local Phone Number
Related Party Transaction [Domain]
Related Party Transaction
Research Milestone [Member]
Research milestone.
Research Milestones
Sanofi Agreement [Member]
Sanofi Agreement [Member]
Sanofi Agreement
Other
Other Liabilities, Current, Total
Other Liabilities, Current
Aggregate fair value of securities, Remaining contractual maturity of greater than one year
Aggregate fair value of securities, Remaining contractual maturity of greater than one year
Aggregate fair value of securities
Auditor Opinion [Text Block]
Auditor Opinion
Restructuring Costs
Restructuring Costs, Total
Restructuring charges incurred during the period
Accounting Policies [Abstract]
Revenue from Contract with Customer, Excluding Assessed Tax, Total
Revenue from Contract with Customer, Excluding Assessed Tax
Revenues
2025
Lessee, Operating Lease, Liability, to be Paid, Year Four
Reconciliation of Operating Profit (Loss) from Segments to Consolidated [Abstract]
Class of Stock [Domain]
Class of Stock
Commercial Paper [Member]
Commercial Paper
External direct expenses
Labor and Related Expense
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Unrecognized stock-based compensation expense, weighted average period expect to recognized
Accrued Professional Fees, Current
Professional services
Stock, Class of Stock [Table]
Schedule Of Stock By Class [Table]
Entity Emerging Growth Company
Entity Emerging Growth Company
Capital Leases, Future Minimum Payments Due, Next 12 Months
Future minimum lease payments, 2020
Tax Credit Carryforward, Name [Domain]
Tax Credit Carryforward, Name