SEC Form 3 
FORM 3	UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940 	  
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1. Name and Address of Reporting Person*
Casdin Capital, LLC	

(Last)	(First)	(Middle)	
1350 AVENUE OF THE AMERICAS	
SUITE 2600	

(Street) 
NEW YORK	NY	10019	

(City)	(State)	(Zip)	
	2. Date of Event Requiring Statement (Month/Day/Year)
07/17/2019 	3. Issuer Name and Ticker or Trading Symbol 
Fulcrum Therapeutics, Inc. [ FULC ] 		
		4. Relationship of Reporting Person(s) to Issuer 
(Check all applicable) 
	Director	X	10% Owner	
	Officer (give title below)		Other (specify below)	
	
	5. If Amendment, Date of Original Filed (Month/Day/Year)				
			6. Individual or Joint/Group Filing (Check Applicable Line) 
	Form filed by One Reporting Person	
X	Form filed by More than One Reporting Person	
	
Table I - Non-Derivative Securities Beneficially Owned	
1. Title of Security (Instr. 4) 	2. Amount of Securities Beneficially Owned (Instr. 4) 	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 	4. Nature of Indirect Beneficial Ownership (Instr. 5) 	
Table II - Derivative Securities Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities) 	
1. Title of Derivative Security (Instr. 4) 	2. Date Exercisable and Expiration Date (Month/Day/Year)	3. Title and Amount of Securities Underlying Derivative Security (Instr. 4) 	4. Conversion or Exercise Price of Derivative Security 	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 	6. Nature of Indirect Beneficial Ownership (Instr. 5) 	
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares				
Series B Preferred Stock	(1) 	(1) 	Common Stock	464,285	(1)	I(2) 	See footnote.	
1. Name and Address of Reporting Person*
Casdin Capital, LLC	

(Last)	(First)	(Middle)	
1350 AVENUE OF THE AMERICAS	
SUITE 2600	

(Street) 
NEW YORK	NY	10019	

(City)	(State)	(Zip)	
	
1. Name and Address of Reporting Person*
Casdin Partners Master Fund, L.P.	

(Last)	(First)	(Middle)	
WALKER HOUSE	
87 MARY STREET	

(Street) 
GEORGE TOWN	E9	KY1-9001	

(City)	(State)	(Zip)	
	
1. Name and Address of Reporting Person*
Casdin Partners GP, LLC	

(Last)	(First)	(Middle)	
1350 AVENUE OF THE AMERICAS	
SUITE 1140	

(Street) 
NEW YORK	NY	10019	

(City)	(State)	(Zip)	
	
1. Name and Address of Reporting Person*
Casdin Eli	

(Last)	(First)	(Middle)	
1350 AVENUE OF THE AMERICAS	
SUITE 1140	

(Street) 
NEW YORK	NY	10019	

(City)	(State)	(Zip)	
	
Explanation of Responses:	
1. The Series B Preferred Stock is convertible into Common Stock on a seven-for-one basis into the number of shares of Common Stock as shown in Column 3 at any time at the holder's election, and automatically upon the closing of the Issuer's initial public offering without payment of further consideration. The shares have no expiration date.	
2. The securities are owned directly by Casdin Partners Master Fund, LP and may be deemed to be indirectly beneficially owned by (i) Casdin Capital, LLC, the investment adviser to Casdin Partners Master Fund, LP, (ii) Casdin Partners GP, LLC, the general partner of Casdin Partners Master Fund LP, and (ii) Eli Casdin, the managing member of Casdin Capital, LLC and Casdin Partners GP, LLC.	
Remarks:	
Each Reporting Person disclaims beneficial ownership in the securities reported on this Form 3 except to the extent of its or his pecuniary interest, if any, therein, and this report shall not be deemed to be an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose.	
	Casdin Partners Master Fund LP, By: Casdin Partners GP, LLC, its General Partner, By: /s/ Eli Casdin, Managing Member	07/17/2019	
	Casdin Capital, LLC, By: /s/ Eli Casdin, Managing Member	07/17/2019	
	Casdin Partners GP LLC, By: /s/ Eli Casdin, Managing Member	07/17/2019	
	/s/ Eli Casdin	07/17/2019	
	** Signature of Reporting Person	Date	
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.	
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).	
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).	
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.	
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