1001 - Document - Cover Page link:presentationLink link:definitionLink link:calculationLink 1002 - Statement - Consolidated Balance Sheets link:presentationLink link:definitionLink link:calculationLink 1003 - Statement - Consolidated Balance Sheets (Parenthetical) link:presentationLink link:definitionLink link:calculationLink 1004 - Statement - Consolidated Statements of Operations and Comprehensive Loss link:presentationLink link:definitionLink link:calculationLink 1005 - Statement - Consolidated Statements of Stockholders' Equity link:presentationLink link:definitionLink link:calculationLink 1006 - Statement - Consolidated Statements of Cash Flows link:presentationLink link:definitionLink link:calculationLink 1007 - Disclosure - Nature of the Business and Basis of Presentation link:presentationLink link:definitionLink link:calculationLink 1008 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:definitionLink link:calculationLink 1009 - Disclosure - Fair Value Measurements link:presentationLink link:definitionLink link:calculationLink 1010 - Disclosure - Cash Equivalents and Marketable Securities link:presentationLink link:definitionLink link:calculationLink 1011 - Disclosure - Property and Equipment, Net link:presentationLink link:definitionLink link:calculationLink 1012 - Disclosure - Additional Balance Sheet Detail link:presentationLink link:definitionLink link:calculationLink 1013 - Disclosure - Preferred Stock link:presentationLink link:definitionLink link:calculationLink 1014 - Disclosure - Common Stock link:presentationLink link:definitionLink link:calculationLink 1015 - Disclosure - Stock-based Compensation Expense link:presentationLink link:definitionLink link:calculationLink 1016 - Disclosure - License and Collaboration Agreements link:presentationLink link:definitionLink link:calculationLink 1017 - Disclosure - Leases link:presentationLink link:definitionLink link:calculationLink 1018 - Disclosure - Commitments and Contingencies link:presentationLink link:definitionLink link:calculationLink 1019 - Disclosure - Income Taxes link:presentationLink link:definitionLink link:calculationLink 1020 - Disclosure - Defined Contribution Plan link:presentationLink link:definitionLink link:calculationLink 1021 - Disclosure - Net (Loss) Income per Share link:presentationLink link:definitionLink link:calculationLink 1022 - Disclosure - Restructuring Activities link:presentationLink link:definitionLink link:calculationLink 1023 - Disclosure - Related-Party Transactions link:presentationLink link:definitionLink link:calculationLink 1024 - Disclosure - Segment Information link:presentationLink link:definitionLink link:calculationLink 1025 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:definitionLink link:calculationLink 1026 - Disclosure - Fair Value Measurements (Tables) link:presentationLink link:definitionLink link:calculationLink 1027 - Disclosure - Cash Equivalents and Marketable Securities (Tables) link:presentationLink link:definitionLink link:calculationLink 1028 - Disclosure - Property and Equipment, Net (Tables) link:presentationLink link:definitionLink link:calculationLink 1029 - Disclosure - Additional Balance Sheet Detail (Tables) link:presentationLink link:definitionLink link:calculationLink 1030 - Disclosure - Common Stock (Tables) link:presentationLink link:definitionLink link:calculationLink 1031 - Disclosure - Stock-based Compensation Expense (Tables) link:presentationLink link:definitionLink link:calculationLink 1032 - Disclosure - Leases (Tables) link:presentationLink link:definitionLink link:calculationLink 1033 - Disclosure - Income Taxes (Tables) link:presentationLink link:definitionLink link:calculationLink 1034 - Disclosure - Net (Loss) Income per Share (Tables) link:presentationLink link:definitionLink link:calculationLink 1035 - Disclosure - Restructuring Activities (Tables) link:presentationLink link:definitionLink link:calculationLink 1036 - Disclosure - Segment Information (Tables) link:presentationLink link:definitionLink link:calculationLink 1037 - Disclosure - Nature of the Business and Basis of Presentation - Additional Information (Details) link:presentationLink link:definitionLink link:calculationLink 1038 - Disclosure - Summary of Significant Accounting Policies - Schedule of the Estimated Useful Life of Related Asset (Details) link:presentationLink link:definitionLink link:calculationLink 1039 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Details) link:presentationLink link:definitionLink link:calculationLink 1040 - Disclosure - Fair Value Measurements - Summary of Financial Assets Measured at Fair Value on Recurring Basis and Level of Fair Value Hierarchy Utilized (Details) link:presentationLink link:definitionLink link:calculationLink 1041 - Disclosure - Fair Value Measurements - Additional Information (Details) link:presentationLink link:definitionLink link:calculationLink 1042 - Disclosure - Cash Equivalents and Marketable Securities - Summary of Marketable Securities (Details) link:presentationLink link:definitionLink link:calculationLink 1043 - Disclosure - Cash Equivalents and Marketable Securities - Additional Information (Details) link:presentationLink link:definitionLink link:calculationLink 1044 - Disclosure - Property and Equipment, Net - Schedule of Property and Equipment, Net (Details) link:presentationLink link:definitionLink link:calculationLink 1045 - Disclosure - Property and Equipment, Net - Additional Information (Details) link:presentationLink link:definitionLink link:calculationLink 1046 - Disclosure - Additional Balance Sheet Detail - Schedule of Prepaid Expenses and Other Current Assets (Details) link:presentationLink link:definitionLink link:calculationLink 1047 - Disclosure - Additional Balance Sheet Detail - Schedule of Accrued Expenses and Other Current Liabilities (Details) link:presentationLink link:definitionLink link:calculationLink 1048 - Disclosure - Preferred Stock - Additional Information (Details) link:presentationLink link:definitionLink link:calculationLink 1049 - Disclosure - Common Stock - Additional Information (Details) link:presentationLink link:definitionLink link:calculationLink 1050 - Disclosure - Common Stock - Schedule of Potential Conversion of Preferred Stock and Future Issuance of Common Stock (Details) link:presentationLink link:definitionLink link:calculationLink 1051 - Disclosure - Stock-based Compensation Expense - Additional Information (Details) link:presentationLink link:definitionLink link:calculationLink 1052 - Disclosure - Stock-based Compensation Expense - Summary of Stock Option Activity (Details) link:presentationLink link:definitionLink link:calculationLink 1053 - Disclosure - Stock-based Compensation Expense - Summary of Weighted Average Assumptions Used to Calculate Fair Value of Stock Option (Details) link:presentationLink link:definitionLink link:calculationLink 1054 - Disclosure - Stock-based Compensation Expense - Summary of Restricted Stock Activity outside of 2019 and 2016 Plan (Details) link:presentationLink link:definitionLink link:calculationLink 1055 - Disclosure - Stock-based Compensation Expense - Summary of Stock-Based Compensation Expense Recognized (Details) link:presentationLink link:definitionLink link:calculationLink 1056 - Disclosure - License and Collaboration Agreements - Additional Information (Details) link:presentationLink link:definitionLink link:calculationLink 1057 - Disclosure - Leases - Schedule of Future minimum lease payments (Details) link:presentationLink link:definitionLink link:calculationLink 1058 - Disclosure - Leases (Additional Information) (Details) link:presentationLink link:definitionLink link:calculationLink 1059 - Disclosure - Commitments and Contingencies - Additional Information (Details) link:presentationLink link:definitionLink link:calculationLink 1060 - Disclosure - Income Taxes - Schedule of Reconciliation of U.S. Federal Statutory Income Tax Rate (Details) link:presentationLink link:definitionLink link:calculationLink 1061 - Disclosure - Income Taxes - Schedule of Deferred Tax Assets and Liabilities (Details) link:presentationLink link:definitionLink link:calculationLink 1062 - Disclosure - Income Taxes - Additional Information (Details) link:presentationLink link:definitionLink link:calculationLink 1063 - Disclosure - Defined Contribution Plan - Additional Information (Details) link:presentationLink link:definitionLink link:calculationLink 1064 - Disclosure - Net (Loss) Income per Share - Schedule of Antidilutive Securities Excluded from Calculation of Diluted Net Loss per Share Attributable to Common Stockholders (Details) link:presentationLink link:definitionLink link:calculationLink 1065 - Disclosure - Segment Information - Schedule of Reportable Segment Revenue, Operating Expenses, and Net Loss (Details) link:presentationLink link:definitionLink link:calculationLink 1066 - Disclosure - Segment Information (Additional Information) (Details) link:presentationLink link:definitionLink link:calculationLink 1067 - Disclosure - Restructuring Activities - Schedule of Restructuring Charges (Details) link:presentationLink link:definitionLink link:calculationLink 1068 - Disclosure - Restructuring Activities (Additional Information) (Details) link:presentationLink link:definitionLink link:calculationLink 1069 - Disclosure - Related-Party Transactions - Additional Information (Details) link:presentationLink link:definitionLink link:calculationLink 1070 - Statement - Consolidated Statements of Cash Flows Alternate 1 link:presentationLink link:definitionLink link:calculationLink Cover [Abstract] Document Information [Table] Document Information [Line Items] Document Type Document Type Amendment Flag Amendment Flag Entity Registrant Name Entity Registrant Name Entity Central Index Key Entity Central Index Key Entity Filer Category Entity Filer Category Entity Small Business Entity Small Business Entity Emerging Growth Company Entity Emerging Growth Company Entity Incorporation, State or Country Code Entity Incorporation, State or Country Code Entity Tax Identification Number Entity Tax Identification Number Entity Address, Address Line One Entity Address, Address Line One Entity Address, City or Town Entity Address, City or Town Entity Address, State or Province Entity Address, State or Province Entity Address, Postal Zip Code Entity Address, Postal Zip Code City Area Code City Area Code Local Phone Number Local Phone Number Entity Primary SIC Number Contact Personnel Name Entity Addresses, Address Type [Axis] Address Type [Domain] Business Contact [Member] Statement of Financial Position [Abstract] Assets [Abstract] Assets Assets, Current [Abstract] Current assets: Cash and Cash Equivalent Cash and cash equivalents Marketable Securities Marketable securities Unbilled Receivables, Current Unbilled accounts receivable Prepaid Expense and Other Assets, Current Prepaid expenses and other current assets Total prepaid expenses and other current assets Assets, Current Total current assets Property, Plant and Equipment, Net Property and equipment, net Property and equipment, net Operating Lease, Right-of-Use Asset Operating lease right-of-use assets Restricted Cash, Noncurrent Restricted cash Other Assets, Noncurrent Other assets Assets Total assets Liabilities and Equity [Abstract] Liabilities and stockholders' equity Liabilities, Current [Abstract] Current liabilities: Accounts Payable, Current Accounts payable Accrued Liabilities And Other Current Liabilities Accrued expenses and other current liabilities Total accrued expenses and other current liabilities Accrued liabilities and other current liabilities. Operating Lease, Liability, Current Operating lease liability, current Liabilities, Current Total current liabilities Operating Lease, Liability, Noncurrent Operating lease liability, excluding current portion Other Liabilities, Noncurrent Other liabilities, excluding current portion Liabilities Total liabilities Commitments and Contingencies Commitments and contingencies (Note 12) Equity, Attributable to Parent [Abstract] Stockholders' equity: Preferred Stock, Value, Issued Preferred stock, $0.001 par value; 5,000,000 shares authorized; no shares issued or outstanding Common Stock, Value, Issued Common stock, $0.001 par value; 200,000,000 shares authorized; 76,285,157 and 66,578,891 shares issued and outstanding as of June 30, 2026 and December 31, 2025, respectively Additional Paid in Capital, Common Stock Additional paid-in capital Accumulated Other Comprehensive Income (Loss), Net of Tax Accumulated other comprehensive gain Retained Earnings (Accumulated Deficit) Accumulated deficit Accumulated deficit Equity, Attributable to Parent Total stockholders' equity Beginning balance Ending balance Liabilities and Equity Total liabilities and stockholders' equity Preferred Stock, Par or Stated Value Per Share Preferred stock, par value Preferred Stock, Shares Authorized Preferred stock, shares authorized Preferred Stock, Shares Issued Preferred stock, shares issued Preferred Stock, Shares Outstanding Preferred stock, shares outstanding Common Stock, Par or Stated Value Per Share Common stock, par value Common Stock, Shares Authorized Common stock, shares authorized Common Stock, Shares, Issued Common stock, shares issued Common Stock, Shares, Outstanding Common stock, shares outstanding Income Statement [Abstract] Revenue from Contract with Customer, Including Assessed Tax Collaboration revenue Operating Expenses [Abstract] Operating expenses: Research and Development Expense Research and development General and Administrative Expense General and administrative Restructuring and Related Cost, Incurred Cost Restructuring expenses Operating Expenses Total operating expenses Operating Expenses Long-Lived Asset, Held and Used, Impairment Loss Impairment of long-lived assets Operating Income (Loss) Loss from operations Loss from operations Interest Income (Expense), Nonoperating Other income, net Net Income (Loss) Attributable to Parent Net loss Net Income (Loss) Earnings Per Share, Basic Net loss per share, Basic Earnings Per Share, Diluted Net loss per share, diluted Weighted Average Number of Shares Outstanding, Diluted Weighted-average common shares outstanding, Diluted Weighted Average Number of Shares Outstanding, Basic Weighted-average common shares outstanding, Basic Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract] Comprehensive loss: Other Comprehensive Income (Loss), Net of Tax [Abstract] Other comprehensive gain: OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax Unrealized gain on marketable securities Unrealized gain or loss on marketable securities Other Comprehensive Income (Loss), Net of Tax Total other comprehensive gain Comprehensive Income (Loss), Net of Tax, Attributable to Parent Comprehensive loss Statement of Stockholders' Equity [Abstract] Statement [Table] Statement [Table] Equity Components [Axis] Equity Components Equity Component [Domain] Equity Component Common Stock [Member] Common Stock Additional Paid-in Capital [Member] Additional Paid-In Capital AOCI Attributable to Parent [Member] Accumulated other comprehensive loss Retained Earnings [Member] Accumulated Deficit Class of Stock [Axis] Class of Stock Class of Stock [Domain] Class of Stock Sale of Stock [Axis] Sale of Stock Sale of Stock [Domain] Sale of Stock Statement [Line Items] Statement [Line Items] Shares, Outstanding Beginning balance, Shares Ending balance, Shares Stock Issued During Period, Value, New Issues Issuance of common stock, net of issuance costs Stock Issued During Period, Shares, New Issues Issuance of common stock, Shares Stock Issued During Period, Value, Employee Benefit Plan Issuance of common stock under employee benefit plans Stock Issued During Period, Shares, Employee Benefit Plan Issuance of common stock under employee benefit plans, Shares Stock Issued During Period, Value, Restricted Stock Award, Gross Vesting of restricted stock awards Stock Issued During Period, Shares, Restricted Stock Award, Gross Vesting of restricted stock awards, Shares Shares reserved for vesting of restricted stock units Issuance of Pre-Funded Warrants in Exchange for Common Stock Value Issuance of pre-funded warrants in exchange for common stock, value Issuance of Pre-Funded Warrants in Exchange for Common Stock Value Issuance of Pre-Funded Warrants in Exchange for Common Stock Shares Issuance of pre-funded warrants in exchange for common stock, Shares Issuance of Pre-Funded Warrants in Exchange for Common Stock Shares Issuance of Common Stock Pursuant to Pre-Funded Warrant Exercise Value Issuance of common stock pursuant to pre-funded warrant exercise Issuance of Common Stock Pursuant to Pre-Funded Warrant Exercise Value Issuance of Common Stock Pursuant to Pre-Funded Warrant Exercise Shares Issuance of common stock pursuant to pre-funded warrant exercise shares Issuance of common stock pursuant to pre-funded warrant exercise shares Issuance of Common Stock Pursuant to Pre-Funded Warrant Exercise Shares APIC, Share-Based Payment Arrangement, Increase for Cost Recognition Stock-based compensation expense Statement of Cash Flows [Abstract] Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract] Operating activities Net Income (Loss), Including Portion Attributable to Noncontrolling Interest Net loss Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract] Adjustments to reconcile net loss to net cash used in operating activities: Depreciation Depreciation expense Share-Based Payment Arrangement, Noncash Expense Stock-based compensation expense Accretion (Amortization) of Discounts and Premiums, Investments Net accretion of discounts on marketable securities Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract] Changes in operating assets and liabilities: Increase (Decrease) in Accounts Receivable Unbilled accounts receivable Increase (Decrease) in Prepaid Expense and Other Assets Prepaid expenses and other current assets Increase Decrease In Operating Lease Assets And Liabilities Operating lease assets and liabilities Increase Decrease In Operating Lease Assets And Liabilities Increase (Decrease) in Other Operating Assets Other assets Increase (Decrease) in Accounts Payable Accounts payable Increase (Decrease) in Accrued Liabilities and Other Operating Liabilities Accrued expenses and other liabilities Cash Provided by (Used in) Operating Activity, Including Discontinued Operation Net cash used in operating activities Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract] Investing activities Payments to Acquire Marketable Securities Purchases of marketable securities Proceeds From Maturity Of Marketable Securities Maturities of marketable securities Proceeds from maturity of marketable securities. Payments to Acquire Property, Plant, and Equipment Purchases of property and equipment Proceeds from Sale of Machinery and Equipment Proceeds received on pending sale of equipment held for sale Cash Provided by (Used in) Investing Activity, Including Discontinued Operation Net cash provided by investing activities Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract] Financing activities Proceeds from Issuance of Common Stock in Connection with Follow-on Offering Proceeds from issuance of common stock and pre-funded warrants in connection with public offerings, net of issuance costs The cash inflow associated with the amount received from entity's secondary offering of stock to the public. Proceeds from Issuance of Common Stock Proceeds from issuance of common stock under benefit plans, net Cash Provided by (Used in) Financing Activity, Including Discontinued Operation Net cash provided by financing activities Payments of Stock Issuance Costs Payments of offering costs associated with the issuance of common stock and pre-funded warrants Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Including Exchange Rate Effect and Discontinued Operation Net increase in cash, cash equivalents and restricted cash Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Including Discontinued Operation Cash, cash equivalents, and restricted cash, beginning of period Cash, cash equivalents, and restricted cash, end of period Total cash, cash equivalents, and restricted cash Supplemental Cash Flow Information [Abstract] Supplemental cash flow information Cash paid for operating lease liabilities Cash paid for operating lease liabilities Cash paid for operating lease liabilities Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract] Non-cash investing and financing activities: Offering Costs Unpaid Offering costs unpaid at end of period Offering Costs Unpaid Financing Receivable, Reclassification to Held-for-Sale Reclassification of equipment to assets held for sale Organization, Consolidation and Presentation of Financial Statements [Abstract] Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block] Nature of the Business and Basis of Presentation Accounting Policies [Abstract] Significant Accounting Policies [Text Block] Summary of Significant Accounting Policies Fair Value Disclosures [Abstract] Fair Value Disclosures [Text Block] Fair Value Measurements Investments, Debt and Equity Securities [Abstract] Cash, Cash Equivalent, and Marketable Security [Text Block] Cash Equivalents and Marketable Securities Property, Plant and Equipment [Abstract] Property, Plant and Equipment Disclosure [Text Block] Property and Equipment, Net Balance Sheet Related Disclosures [Abstract] Supplemental Balance Sheet Disclosures [Text Block] Additional Balance Sheet Detail Temporary Equity Disclosure [Abstract] Preferred Stock [Text Block] Preferred Stock Equity [Abstract] Equity [Text Block] Common Stock Share-Based Payment Arrangement [Abstract] Share-Based Payment Arrangement [Text Block] Stock-based Compensation Expense