Washington, D.C. 20549


Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB Number: 3235-0104
Estimated average burden
hours per response: 0.5
1. Name and Address of Reporting Person*
Morabito Christopher

(Last) (First) (Middle)


(City) (State) (Zip)
2. Date of Event Requiring Statement (Month/Day/Year)
3. Issuer Name and Ticker or Trading Symbol
Fulcrum Therapeutics, Inc. [ FULC ]
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
Director 10% Owner
X Officer (give title below) Other (specify below)
Chief Medical Officer
5. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
X Form filed by One Reporting Person
Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4) 2. Amount of Securities Beneficially Owned (Instr. 4) 3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 4. Nature of Indirect Beneficial Ownership (Instr. 5)
No securities are beneficially owned 0 D
Table II - Derivative Securities Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4) 2. Date Exercisable and Expiration Date (Month/Day/Year) 3. Title and Amount of Securities Underlying Derivative Security (Instr. 4) 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 6. Nature of Indirect Beneficial Ownership (Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Explanation of Responses:
Exhibit Index: 24.1 Power of Attorney
/s/ Peter Thomson, as attorney-in-fact for Christopher Morabito 05/12/2021
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
                                                                    Exhibit 24.1

         	             LIMITED POWER OF ATTORNEY

          Know all by these presents, that the undersigned hereby makes,
  constitutes and appoints each of Bryan Stuart, Curt Oltmans and Peter Thomson,
  signing singly and each acting individually, as the undersigned's true and
  lawful attorney-in-fact with full power and authority as hereinafter
  described to:

     (1)  execute for and on behalf of the undersigned, in the undersigned's
  capacity as an officer and director of Fulcrum Therapeutics, Inc. (the
  "Company"), Forms 3, 4, and 5 (including any amendments thereto) in accordance
  with Section 16(a) of the Securities Exchange Act of 1934, as amended, and the
  rules thereunder (the "Exchange Act");

     (2)  do and perform any and all acts for and on behalf of the undersigned
  which may be necessary or desirable to prepare, complete and execute any such
  Form 3, 4, or 5, prepare, complete and execute any amendment or amendments
  thereto, and timely deliver and file such form with the United States
  Securities and Exchange Commission (the "SEC") and any stock exchange or
  similar authority, including without limitation the filing of a Form ID,
  Update Passphrase, or any other application materials to enable the
  undersigned to gain or maintain access to the Electronic Data Gathering,
  Analysis and Retrieval system of the SEC;

     (3)  seek or obtain, as the undersigned's representative and on the
  undersigned's behalf, information regarding transactions in the Company's
  securities from any third party, including brokers, employee benefit plan
  administrators and trustees, and the undersigned hereby authorizes any such
  person to release any such information to such attorney-in-fact and approves
  and ratifies any such release of information; and

     (4)  take any other action of any type whatsoever in connection with the
  foregoing which, in the opinion of such attorney-in-fact, may be of benefit
  to, in the best interest of, or legally required by, the undersigned, it being
  understood that the documents executed by such attorney-in-fact on behalf of
  the undersigned pursuant to this Power of Attorney shall be in such form and
  shall contain such terms and conditions as such attorney-in-fact may approve
  in such attorney-in-fact's discretion.

          The undersigned hereby grants to each such attorney-in-fact full power
  and authority to do and perform any and every act and thing whatsoever
  requisite, necessary, or proper to be done in the exercise of any of the
  rights and powers herein granted, as fully to all intents and purposes as the
  undersigned might or could do if personally present, with full power of
  substitution or revocation, hereby ratifying and confirming all that such
  attorney-in-fact, or such attorney-in-fact's substitute or substitutes, shall
  lawfully do or cause to be done by virtue of this power of attorney and the
  rights and powers herein granted.  The undersigned acknowledges that the
  foregoing attorneys-in-fact, in serving in such capacity at the request of
  the undersigned, are not assuming nor relieving, nor is the Company assuming
  nor relieving, any of the undersigned's responsibilities to comply with
  Section 16 of the Exchange Act. The undersigned acknowledges that neither the
  Company nor the foregoing attorneys-in-fact assume (i) any liability for the
  undersigned's responsibility to comply with the requirements of the Exchange
  Act, (ii) any liability of the undersigned for any failure to comply with such
  requirements, or (iii) any obligation or liability of the undersigned for
  profit disgorgement under Section 16(b) of the Exchange Act.

          This Power of Attorney shall remain in full force and effect until the
  undersigned is no longer required to file Forms 3, 4, and 5 with respect to
  the undersigned's holdings of and transactions in securities issued by the
  Company, unless earlier revoked by the undersigned in a signed writing
  delivered to the foregoing attorneys-in-fact.

          IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney
  to be executed as of this 11th day of May, 2021.

                                        /s/ Christopher Morabito
                                        Name:  Christopher Morabito